منابع مشابه
PBX proteins: much more than Hox cofactors.
Pre-B cell leukaemia transcription factors (PBXs) were originally identified as Hox cofactors, acting within transcriptional regulation complexes to regulate genetic programs during development. Increasing amount of evidence revealed that PBX function is not restricted to a partnership with Hox or homeodomain proteins. Indeed, PBXs are expressed throughout murine embryonic development and are i...
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A brief overview of the impact of light on the circadian system is given, which underscores the importance of developing a framework for circadian photometry. The amount of light, its spectral composition, spatial distribution, timing and duration needed for vision is so different from that needed for circadian functioning, that generalizations about “good lighting” will have to be assessed by ...
متن کاملMuch more than cigarette smoking
The human condition made fragile by fear of death, by affective distress, by diseases, and by aging compels human beings to search for pleasure. The use of licit or illicit drugs is a good example of this fact. Often, this occurs in such an intense way that it condemns individuals to premature death or a subjugated life. To compound this situation, Western society is continuously bombarded by a...
متن کاملTargeting HOX/PBX dimers in cancer
The HOX and PBX gene families encode transcription factors that have key roles in establishing the identity of cells and tissues in early development. Over the last 20 years it has become apparent that they are also dysregulated in a wide range of solid and haematological malignancies and have a predominantly pro-oncogenic function. A key mode of transcriptional regulation by HOX and PBX protei...
متن کاملLeptin--much more than a satiety signal.
Much attention has focused on the effects of leptin as a central satiety agent. There is now a significant amount of evidence that leptin is active in the periphery. This review focuses on the ability of leptin to modify insulin sensitivity, tissue metabolism, stress responses, and reproductive function. Leptin's effect on several of these systems is mediated via the hypothalamic-pituitary axis...
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ژورنال
عنوان ژورنال: The International Journal of Developmental Biology
سال: 2008
ISSN: 0214-6282
DOI: 10.1387/ijdb.072304al